Mesotherapy is a contemporary non-surgical skin rejuvenation method, widely used in medical practice, which is performed by injecting into or under the skin special medications and vitamins. The key point of this method lies in the repeated injections of pharmaceuticals, vitamins and other ingredients into subcutaneous cellular tissue. The choice of the agent being used for injections will depend on the nature of the issue to be solved. This can be a variety of meso-cocktails, consisting of different medications and vitamins. The composition of meso-cocktails may include antioxidants, microelements, amino acids, etc. The types of mesotherapy are as follows: mixed, epidermal, dermal, deep dermal surface dermal, as well as homeopathic, fitomesothery, biomesotherapy, non-injective, aesthetic (face and body), and remedial. Mesotherapy is applied to treat inflammation, at any stage, all kinds of pain (acute and chronic), immune system diseases, treatment in the field of gynecology, abdominal treatment, varicose veins, rosacea, atherosclerosis or any microcirculatory disorders and the treatment of upper respiratory tract. In recent years, mesotherapy has been applied in cosmetology, and is used to treat acne, wrinkles, skin aging issues, pigmentation disorders, and so on. Among the benefits of mesotherapy the absence of age restrictions, shallow injection of medications and compatibility with other procedures should be noted. Procedures are carried with intervals of 7 - 10 days, during 8 or 10 sessions, depending on the issue to be solved. The results of treatment are retained up to 12 months. If necessary, a second course is recommended after 12 - 18 months. After the procedure, within 2 days, the patient should avoid staying in the sun, visiting sauna or solarium, and avoid excessive physical activity. Within 24 hours after the procedure it is not recommended to use make-up on the surface that underwent treatment. This type of treatment can cause adverse reactions such as swelling, bruising, local allergy, erythema, vasodilation. Mesotherapy should be avoided by patients who have allergic reactions and intolerance to certain medications and / or their components, as well as people with kidney and liver failure, blood disease, patients with epilepsy and cancer. In addition, mesotherapy is not recommended for pregnant and lactating women. The following companies are considered as leading among the manufacturers of mesotherapy products: Filorga, Allergan, VIVACY, Surface, Mesoestetic and REVITACARE.